Objective The aim of the study was to determine right and remaining ventricle deformation parameters in patients with transposition of Retigabine (Ezogabine) the great arteries who had undergone atrial or arterial switch procedures. individuals (75% males 28.7 years) who underwent atrial switch operation and 20 patients (60% males 17.7 years) who underwent arterial switch operation were included in the study. Four chamber and short-axis cine images were used to determine longitudinal and circumferential strain and strain rate using Vector Retigabine (Ezogabine) Velocity Imaging software. Results Compared to the arterial switch group the atrial switch group had decreased right ventricular ejection portion and improved end-diastolic and end-systolic quantities; Retigabine (Ezogabine) and no difference in remaining ventricular ejection portion and quantities. The atrial switch group experienced decreased longitudinal and circumferential strain and strain rate. When compared to normal settings multiple strain guidelines in the atrial switch group were reduced. Conclusions Myocardial deformation analysis of transposition individuals reveals a reduction of right ventricular function and decreased longitudinal and circumferential strain parameters in individuals with an atrial switch operation compared to those with arterial switch operation. A better understanding of the mechanisms of RV failure in TGA may lead to improved treatments and adaptation. in both the atrial and arterial switch organizations and in the control group. The mean age for the control group was 32.6±2.1 years atrial switch was 28.7± 1.8 years and the arterial switch group was 17.7±1.9 years. The BSA was 1.9 m2 for the control and atrial switch group compared to 1.6 m2 for the arterial switch group. This difference was likely due the difference in the imply age of the population at the time of the study. The systolic and diastolic blood pressures were not significantly different between the organizations. Comorbidities among the atrial switch group included one individual with severe and three with moderate tricuspid regurgitation; one individual had severe pulmonary insufficiency; all individuals were in normal sinus rhythm except one who was in junctional rhythm; no baffle obstruction or outflow problems were mentioned. In the arterial switch group two individuals experienced moderate aortic insufficiency; four experienced moderate aortic root dilatation. Inter-observer and Intra-observer Variability Using the Kendall rank correlation coefficient test (τ) for inter- observer variability showed excellent agreement for the RV longitudinal strain actions (τ =0.84 p<0.0001) and moderate agreement for circumferential strain (τ = 0.52 p<0.005). Intra-observer actions showed related reproducibility for longitudinal strain (τ =0.84 p<0.0001) and circumferential strain (τ = 0.77 p<0.0001). Using the Bland-Altman’s storyline to analyze for inter- and intra-observer variability the bias and the Bland-Altman limits of agreement for longitudinal strain was +0.4±3.1% and +0.3±2.4 % for inter-observer and intra-observer observations respectively. For circumferential strain the bias and Bland-Altman limits of agreement ranged from ?0.8±4.0% and ?0.2±2.3% for inter-observer and intra-observer observations respectively. Retigabine (Ezogabine) Both observers were non-blinded. Ventricular Quantities and Ejection Portion The RV ejection portion was lower by almost 15% in the atrial switch group compared to the arterial switch group. This reduction in function was accompanied by a significant increase in complete RV end-diastolic and end-systolic quantities in the atrial switch group (Fig 2). The LV Smad7 ejection portion Retigabine (Ezogabine) was decreased by 6% in the atrial switch compared to the arterial switch group with significant decrease in end-diastolic LV quantities and no significant difference in the complete LV end-systolic and end-diastolic quantities. Fig 2 Assessment of Right Ventricle (RV) and Remaining Ventricle (LV) Function and Volume between the Atrial Switch (AS) and Arterial Switch (ASO) group. (*) shows statistical significance with p ideals ??0.05. (A) Pub graphs represent significantly … RV Deformation guidelines The deformation guidelines of the RV and LV of the atrial switch arterial switch Retigabine (Ezogabine) and normal control organizations are demonstrated in Furniture 2 and Fig 3. When compared across organizations the atrial switch RV strain parameters showed a significant.