to the Society of Thoracic Surgeons database approximately 11% of patients who underwent aortic root replacement between January 2000 and June 2011 received a valve-sparing process. characteristics of this procedure. Perhaps the most important point that we learned relatively early on was that the reimplantation process was superior to the remodeling process because of its stabilization of the annulus. Since this discovery numerous iterations of the reimplantation GM 6001 operation have been suggested and performed. In this issue of the Journal Dr Miller1 provides an excellent and concise summary of the history and development of the valve-sparing aortic root replacement with specific attention to the various iterations of the David reimplantation operation. In addition he explains the outstanding results of his own series of 331 patients at Stanford University or college. Of these patients 284 underwent a David V ��Stanford modification�� operation of Dr Miller��s own design in which an appropriately GM 6001 sized tailored and proximally plicated graft is used to enclose the aortic valve followed by use of a second smaller distal graft for accurate remodeling of the sinotubular junction. The results of this operation are indeed admirable at 10 years showing 92% �� 4% freedom from aortic root reoperation and 96 �� 2% freedom from structural valve deterioration. Particularly amazing is that 38% of GM 6001 the patients in this series experienced Marfan syndrome and 29%had bicuspid aortic valves. Currently many modifications of the reimplantation technique of valve-sparing aortic root replacement are being used with success. Some centers have continued to use the initial David I (which uses a simple straight graft) with good results.2 Others have followed the progression of the David operation with a larger graft as with the David V modification variably with or without the Stanford modification to neck down the neo-sinotubular junction.3 Whether the proximal portion of the graft enclosing the annulus and valve must be separately plicated before implantation still remains somewhat controversial. Many surgeons do ARL11 not perform this step but rather rely on the subannular sutures placed across the graft to plicate it when tied.3 4 Whether omission of this step will result in late dilatation of the annulus remains uncertain and it is therefore also uncertain whether omission of this step will contribute to long term aortic insufficiency. Of course the only way truly to reconcile this point would be to conduct a prospective randomized assessment of plicated versus nonplicated grafts a study that seems unlikely to ever be undertaken. Although proximal plication of the graft is certainly reasonable an important technical point is that care must be taken not to further plicate it through the tying of the subannular sutures. It can be relatively easy to introduce a small plication into the graft with the tying of each suture the sum total of which can constitute a significant narrowing of the left ventricular outflow tract. Unlike Dr Miller��s technique I and others prefer to stabilize the annulus with an appropriately sized Hegar dilator to avoid this potential complication. This step seems particularly germane when this procedure is performed in an academic center where residents are taught this operation but do not yet possess the same amount of skill as a seasoned aortic surgeon. These points make Dr Miller��s results even more remarkable because in his hands the vast majority of these operations had significant resident input. This indeed is a testament to Dr Miller��s remarkable surgical educational skills and in my opinion in part provides justification for his inheritance of the title of the ��world��s best first assistant�� from Norman Shumway. Other versions of the David valve-sparing aortic root replacement procedure include use of a Valsalva-type graft. Although the use of this graft has been criticized for its lack of capacity to be tailored to varying aortic valve commissural heights many authors have used it with excellent results and have asserted that this lack has not been an issue.5 6 The extent GM 6001 of proximal anchoring of this graft is also variable with circumferential fixation reported by some authors and only partial fixation by others (for example only 3 stitches placed 1 under the nadir of each sinus by the Hopkins Group).6 In addition other variations of the reimplantation valve-sparing aortic root operation have been used successfully. One such operation is the University of GM 6001 Florida ��sleeve�� operation a simplified operation in which a.