Purpose The Dixon methods provide consistent water-fat separation but need multiple image models which extend the entire acquisition period. using either image-domain (LEENA-S) or k-space site (LEENA-G) parallel imaging ways to reconstruct water-only and fat-only pictures. An off-resonance modification technique was integrated to boost the uniformity from the water-fat parting. Results Standard water-fat parting was accomplished for both LEENA-S and LEENA-G options for phantom and body and calf imaging applications at 1.5T and 3T The resultant drinking water and extra fat pictures were identical to regular 2-point Dixon and fat-suppressed pictures qualitatively. Summary The LEENA-G and LEENA-S strategies provide standard drinking water and body fat pictures from an individual MRI acquisition. These straightforward strategies could be adapted to AZD1152 at least one 1.5T and 3T medical MRI scanners and provide similar extra fat/drinking water separation with regular 2-stage fat-suppression and Dixon methods. Keywords: water extra fat imaging extra fat suppression MRI parallel imaging Feeling GRAPPA Introduction Extra fat suppression can be an essential component on all contemporary MRI systems just because a wide selection of anatomic and pathologic constructions could be obscured from the normally shiny adipose cells. The necessity for effective lipid/off-resonance sign suppression is particularly critical in fast imaging acquisitions such as for example echo-planar imaging and non-Cartesian acquisitions (eg spiral trajectories) where off-resonance spins can lead to ghosting artifacts and picture blurring respectively. From the multiple extra Itgb4 fat suppression methods the Dixon strategies provide not merely uniform extra fat suppression but also the prospect of lipid quantification (1). These methods are excellent alternatives towards the short-tau inversion recovery AZD1152 (2) and spectral excitation extra fat suppression strategies (3) with regards to both uniform extra fat suppression and quantitative features (4 5 The initial Dixon method 1st suggested in 1984 acquires two distinct pictures in which drinking water and extra fat magnetization vectors possess a 0° and a 180° stage difference respectively to create separated water-only AZD1152 and fat-only pictures (1). This technique is named 2-stage Dixon (2PD). Since that time many variants from the Dixon methods have been created and can become generally sorted into single-point (6 7 two-point (1 8 three-point (14-18) and higher-order strategies (19-24) based on how many pictures are obtained. Fundamentally these methods require multiple picture models at different echo instances which can considerably extend the entire acquisition time. Therefore could limit picture spatial quality and/or slice insurance coverage in body imaging which are usually obtained during breath-holding. One simple approach to decrease the general acquisition time can be to put into action parallel imaging strategies such as for example level of sensitivity encoding (Feeling (25)) or generalized autocalibrating partly parallel acquisitions (GRAPPA (26)) (27) or compressed sensing methods (28 29 or both (30 31 to diminish the acquisition period for each specific image. An alternative solution scheme lipid eradication with an echo-shifting N/2-ghost acquisition (LEENA) runs on the specific trajectory and modified parallel imaging ways to reconstruct the water-only and fat-only pictures. In an initial research LEENA was proven to reliably suppress adipose cells signal by merging this specialised trajectory having a SENSE-like N/2-ghost reconstruction (32). With this research the LEENA acquisition and reconstruction strategy was prolonged to be utilized in conjunction with either image-domain or k-space site parallel imaging methods [ie Feeling (25) and GRAPPA (26)]. Both of these methods are known as LEENA-S (LEENA acquisition having a SENSE-like reconstruction) and LEENA-G (LEENA acquisition with GRAPPA-like reconstruction) respectively. Furthermore these procedures could be effectively coupled with off-resonance modification techniques to guarantee uniform drinking water and extra fat pictures. In this research the LEENA trajectory was applied in an instant steady-state free of charge precession (FISP) series to generate pictures with ghosting from the fatty cells. Distinct water-only and fat-only pictures are generated using the LEENA-S or LEENA-G reconstruction strategies after that. The capabilities from the LEENA-G and LEENA-S techniques are demonstrated in phantom.