Background The liver organ is the major site of Hepatitis B disease and Hepatitis C disease replications. positive for Hepatitis C disease, respectively. History of blood transfusion (95% CI, 1.36C12.71) and unprotected sex (95% CI, 1.25C10.15) were significantly associated with Hepatitis B disease illness, while the type of diabetes (95% CI, 1.25C10.89) was associated with anti-Hepatitis C virus positivity. SCH-1473759 hydrochloride Summary Positivity for Hepatitis C disease was significantly associated with Type II diabetes. Blood transfusion and unprotected sex were risk factors for Hepatitis B disease infections. Further studies that sophisticated temporal associations and find out explanations for the relationship between diabetes and Hepatitis C viral infections are of paramount importance. Keywords: HBV, HCV, DM, co-infection Background In adult, Hepatitis B Disease (HBV) illness usually resolves and evolves protecting immunity, but Hepatitis C Disease (HCV) illness tends to progress into a chronic illness in most causalities. The incidence of liver cirrhosis or hepatic cell carcinoma (HCC) is definitely high among individuals Kit with chronic HBV and/or HCV infections.1,2 Moreover, HCV has been displayed to produce extrahepatic manifestations.3 The World Health Organization (WHO) estimated that about 350 million people are infected with chronic HBV, and 170 million suffer from chronic HCV infection worldwide.4C6 Diabetes mellitus is a disease condition that encompasses a group of metabolic disorders regarded as hyperglycemia following irregularities in the secretion or action of insulin or both According to American Diabetes Association (ADA), you will find three ways to diagnose diabetes are possible: Symptoms of diabetes plus casual plasma glucose concentration greater than or equal to 200 mg/dL (11.1 mmol/), Fasting Plasma Glucose (FPG) greater SCH-1473759 hydrochloride than or equal to 126 mg/dL (7.0 mmol/L) and 2 hrs post-load glucose greater than or equal to 200 mg/dL (11.1 mmol/L) during an oral glucose tolerance test (OGTT).7 It has been perceived to be rigorously linked with advanced age, obesity, and lack of exercise. On the other hand, studies have shown that hepatitis might contribute to the development of diabetes.8,9 Conversely, a study highlighted that diabetes patients are at high risk for the infection because they are subjected to more frequent medical interventions.10 The liver contributes a significant part in glucose metabolism. Hence, efficient liver function is vital to retain glucose homeostasis. The International Diabetes Federation (IDF) estimated that 415 million adults experienced diabetes and SCH-1473759 hydrochloride that the digit will rise to 642 million by 2040. Therefore, diabetes has grown into a severe public health problem.11 The seroprevalence of hepatitis B and hepatitis C has SCH-1473759 hydrochloride been studied among people with a low sensitive method, rapid test kit, inside a non-comparative way and on a small sample which was difficult to SCH-1473759 hydrochloride reach a conclusion about hepatitis infections among diabetic and non-diabetic groups, especially in our study area. We thus determined the prevalence of HCV and HBV infection among diabetic and non-diabetic people. Methods A comparative cross-sectional study was conducted from October 2016 to February 2017 at the University of Gondar referral teaching hospital, northwest Ethiopia. The hospital had a range of specialties, 400 beds, over 400 staff and provides referral services to about five million people in the region. The diabetic clinic at the University of Gondar referral teaching hospital was established in 1985 and has been giving services to 5022 registered DM patients and 3024 of them were type II victims. Diabetes mellitus patients who were on treatment and visiting the diabetic clinic for check-ups were systematically recruited. Voluntary blood donors at the University of Gondar referral teaching hospital with FBS < 100 mg/dL or RBS <126 mg/dL were considered.